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Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin

Moretti, Diego ; Mettler, Samuel ; Zeder, Christophe ; Lundby, Carsten ; Geurts-Moetspot, Anneke ; Monnard, Arnaud ; Swinkels, Dorine W. ; Brittenham, Gary M. ; Zimmermann, Michael B.

In: The American Journal of Clinical Nutrition, 2018, vol. 108, no. 6, p. 1324-1333

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

Lathuilière, Aurélien ; Laversenne, Vanessa ; Astolfo, Alberto ; Kopetzki, Erhard ; Jacobsen, Helmut ; Stampanoni, Marco ; Bohrmann, Bernd ; Schneider, Bernard L. ; Aebischer, Patrick

In: Brain, 2016, vol. 139, no. 5, p. 1587-1604

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Kidney-synthesized erythropoietin is the main source for the hypoxia-induced increase in plasma erythropoietin in adult humans

Lundby, Anne-Kristine ; Keiser, Stefanie ; Siebenmann, Christoph ; Schäffer, Leonhard ; Lundby, Carsten

In: European Journal of Applied Physiology, 2014, vol. 114, no. 6, p. 1107-1111

Prevalence of hepatitis and HIV infections and vaccination rates in patients entering the heroin-assisted treatment in Switzerland between 1994 and 2002

Gerlich, Miriam ; Gschwend, Patrick ; Uchtenhagen, Ambros ; Krämer, Alexander ; Rehm, Jürgen

In: European Journal of Epidemiology, 2006, vol. 21, no. 7, p. 545-549

Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear

Monge Naldi, Arianne ; Gassmann, Max ; Bodmer, Daniel

In: Cellular and Molecular Life Sciences, 2009, vol. 66, no. 22, p. 3595-3599

Immunization in children with chronic renal failure: a practical approach

Neuhaus, Thomas

In: Pediatric Nephrology, 2004, vol. 19, no. 12, p. 1334-1339

Erythropoietin modulates the neural control of hypoxic ventilation

Gassmann, Max ; Soliz, Jorge

In: Cellular and Molecular Life Sciences, 2009, vol. 66, no. 22, p. 3575-3582