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A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

Lathuilière, Aurélien ; Laversenne, Vanessa ; Astolfo, Alberto ; Kopetzki, Erhard ; Jacobsen, Helmut ; Stampanoni, Marco ; Bohrmann, Bernd ; Schneider, Bernard L. ; Aebischer, Patrick

In: Brain, 2016, vol. 139, no. 5, p. 1587-1604

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    Titel
    • A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies
    Autor
    • Lathuilière, Aurélien. Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
    • Laversenne, Vanessa. Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
    • Astolfo, Alberto. Swiss Light Source, Paul Scherrer Institute (PSI), 5232, Villigen-PSI, Switzerland
    • Kopetzki, Erhard. Pharma Research and Early Development, DTA Neuroscience, Roche Innovation Center Penzberg, F. Hoffmann-La Roche, Switzerland
    • Jacobsen, Helmut. Pharma Research and Early Development, DTA Neuroscience, Roche Innovation Center Basel, F. Hoffmann-La Roche, Switzerland
    • Stampanoni, Marco. Swiss Light Source, Paul Scherrer Institute (PSI), 5232, Villigen-PSI, Switzerland
    • Bohrmann, Bernd. Pharma Research and Early Development, DTA Neuroscience, Roche Innovation Center Basel, F. Hoffmann-La Roche, Switzerland
    • Schneider, Bernard L.. Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
    • Aebischer, Patrick. Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Brain, 2016, vol. 139, no. 5, p. 1587-1604. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:331096
    Summary
    Passive immunization against toxic misfolded proteins could offer protection against neurodegenerative disease. Lathuilière et al . report the development of a retrievable device to encapsulate cells secreting recombinant anti-amyloid-β antibodies. When implanted in mouse models of Alzheimer's disease, the system delivers antibodies to the brain and reduces amyloid and tau pathologies.