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Université de Fribourg

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...

Université de Fribourg

Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy

Eisele, Nicole ; Klossner, Rahel ; Escher, Geneviève ; Rudloff, Stefan ; Larionov, Alexey ; Theilig, Franziska ; Mohaupt, Markus G. ; Mistry, Hiten D. ; Gennari‐Moser, Carine

In: Journal of the American Heart Association, 2018, p. -

In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears contra‐ intuitive. We hypothesize that an appropriate Na+ intake in pregnancy reduces maternal BP and adapts the renin‐angiotensin system in a...