Ergebnisse einschränken

Dokumententyp

Sprache

Université de Fribourg

Inference of natural selection from ancient DNA

Dehasque, Marianne ; Ávila‐Arcos, María C. ; Díez‐del‐Molino, David ; Fumagalli, Matteo ; Guschanski, Katerina ; Lorenzen, Eline D. ; Malaspinas, Anna‐Sapfo ; Marques‐Bonet, Tomas ; Martin, Michael D. ; Murray, Gemma G. R. ; Papadopulos, Alexander S. T. ; Therkildsen, Nina Overgaard ; Wegmann, Daniel ; Dalén, Love ; Foote, Andrew D.

In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108

Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...

Université de Fribourg

Affective cognition in bipolar disorder: A systematic review by the ISBD targeting cognition task force

Miskowiak, Kamilla W. ; Seeberg, Ida ; Kjaerstad, Hanne L. ; Burdick, Katherine E. ; Martinez‐Aran, Anabel ; Bonnin, Caterina del Mar ; Bowie, Christopher R. ; Carvalho, Andre F. ; Gallagher, Peter ; Hasler, Gregor ; Lafer, Beny ; López‐Jaramillo, Carlos ; Sumiyoshi, Tomiki ; McIntyre, Roger S. ; Schaffer, Ayal ; Porter, Richard J. ; Purdon, Scot ; Torres, Ivan J. ; Yatham, Lakshmi N. ; Young, Allan H. ; Kessing, Lars V. ; Rheenen, Tamsyn E. Van ; Vieta, Eduard

In: Bipolar Disorders, 2019, p. -

Background: Impairments in affective cognition are part of the neurocognitive profile and possible treatment targets in bipolar disorder (BD), but the findings are heterogeneous. The International Society of Bipolar Disorder (ISBD) Targeting Cognition Task Force conducted a systematic review to (i) identify the most consistent findings in affective cognition in BD, and (ii) provide...

Université de Fribourg

Ice-penetrating radar survey of the subsurface debris field at Camp Century, Greenland

Karlsson, Nanna B. ; Colgan, William T. ; Binder, Daniel ; Machguth, Horst ; Abermann, Jakob ; Hansen, Karina ; Pedersen, Allan Ø.

In: Cold Regions Science and Technology, 2019, vol. 165, p. 102788

The warming climate is changing the surface dynamics of the Greenland Ice Sheet, including the balance between snowfall and melt. Increasing surface melt impacts the structure of the relatively porous near-surface layer known as firn. Camp Century, a base abandoned in 1967, now comprises a subsurface debris field within the firn in Northwest Greenland. We collected 80 km of 100 or 250 MHz...

Università della Svizzera italiana

Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts

Kassem, Maher M. ; Christoffersen, Lars B. ; Cavalli, Andrea ; Lindorff-Larsen, Kresten

In: Scientific reports, 2018, vol. 8, no. 1, p. 11112

Based on the development of new algorithms and growth of sequence databases, it has recently become possible to build robust higher-order sequence models based on sets of aligned protein sequences. Such models have proven useful in de novo structure prediction, where the sequence models are used to find pairs of residues that co-vary during evolution, and hence are likely to be in spatial...