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Trends in incidence and medical resource utilisation in patients with chronic lymphocytic leukaemia: insights from the UK Clinical Practice Research Datalink (CPRD)

Pfeil, A. ; Imfeld, P. ; Pettengell, R. ; Jick, S. ; Szucs, T. ; Meier, Christoph ; Schwenkglenks, M.

In: Annals of Hematology, 2015, vol. 94, no. 3, p. 421-429

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    Titre
    • Trends in incidence and medical resource utilisation in patients with chronic lymphocytic leukaemia: insights from the UK Clinical Practice Research Datalink (CPRD)
    Auteur
    • Pfeil, A.. Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland
    • Imfeld, P.. Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Spitalstrasse 26, 4031, Basel, Switzerland
    • Pettengell, R.. Cellular and Molecular Medicine, St. George's University of London, London, UK
    • Jick, S.. Boston Collaborative Drug Surveillance Program, Boston University School of Public Health, Lexington, MA, USA
    • Szucs, T.. Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland
    • Meier, Christoph. Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Spitalstrasse 26, 4031, Basel, Switzerland
    • Schwenkglenks, M.. Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Hematology, 2015, vol. 94, no. 3, p. 421-429. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:333081
    Summary
    Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in European adults. We aimed to evaluate time trends in CLL incidence and medical resource utilisation of CLL patients in the UK. We conducted a retrospective, observational cohort analysis using the UK Clinical Practice Research Datalink (CPRD) comprising mainly primary care data. We included adult patients with newly diagnosed CLL between January 2000 and June 2012. Descriptive and trend analyses of CLL incidence and medical resource utilisation were performed. A total of 2576 patients with CLL met the eligibility criteria. At diagnosis, the majority of patients (71.7%) were above 65years of age. The European age-standardised CLL incidence rate in the CPRD was 6.2/100,000 (95% confidence interval [CI] 6.0, 6.5/100,000) person-years. There was no statistically significant increase over time. The CLL patients had on average 74.6 general practitioner visits during a median follow-up of 3.3years. Between 2000 and 2012, the average number of recorded hospitalisations and referrals per year corrected for duration of follow-up significantly (p < 0.001) increased by 8.1% (95% CI 6.8%, 9.3%) and 16.4% (95% CI 15.4%, 17.3%), respectively. Referrals and hospitalisations in the second year compared to the first year following the CLL diagnosis significantly decreased. CLL incidence rates in the CPRD were stable over the period from 2000 to 2012. Medical resource utilisation in UK primary care was well documented, but further research is needed to describe secondary and tertiary care medical resource utilisation e.g. chemotherapy administration, which is inadequately captured in the CPRD.