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Host genetics of invasive Aspergillus and Candida infections

Wójtowicz, Agnieszka ; Bochud, Pierre-Yves

In: Seminars in Immunopathology, 2015, vol. 37, no. 2, p. 173-186

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    Titre
    • Host genetics of invasive Aspergillus and Candida infections
    Auteur
    • Wójtowicz, Agnieszka. Infectious Disease Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland
    • Bochud, Pierre-Yves. Infectious Disease Service, Department of Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Seminars in Immunopathology, 2015, vol. 37, no. 2, p. 173-186. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:333016
    Summary
    Invasive candidiasis and aspergillosis are major complications in surgical and onco-hematological patients, and still associated with an important morbidity and mortality. A large number of studies highlighted the potential role of host genetic polymorphisms that may influence susceptibility to fungal pathogens, but many were limited by insufficient statistical power, problematic design, and/or lack of replication. However, some relevant polymorphisms are now emerging from well-conducted studies whose associations have been replicated and/or are supported by strong biological evidence. Such polymorphisms together with other biomarkers may play a role in the prediction, diagnosis, and management of severe fungal infections in high-risk patients in the coming years.