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Structural aspects of fungal allergens

Crameri, Reto

In: Seminars in Immunopathology, 2015, vol. 37, no. 2, p. 117-121

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    Titre
    • Structural aspects of fungal allergens
    Auteur
    • Crameri, Reto. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Seminars in Immunopathology, 2015, vol. 37, no. 2, p. 117-121. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:332788
    Summary
    Despite the increasing number of solved crystal structures of allergens, the key question why some proteins are allergenic and the vast majority is not remains unanswered. The situation is not different for fungal allergens which cover a wide variety of proteins with different chemical properties and biological functions. They cover enzymes, cell wall, secreted, and intracellular proteins which, except cross-reactive allergens, does not show any evidence for structural similarities at least at the three-dimensional level. However, from a diagnostic point of view, pure allergens biotechnologically produced by recombinant technology can provide us, in contrast to fungal extracts which are hardly producible as standardized reagents, with highly pure perfectly standardized diagnostic reagents.