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Coronary artery calcium quantification from contrast enhanced CT using gemstone spectral imaging and material decomposition

Fuchs, Tobias ; Stehli, Julia ; Dougoud, Svetlana ; Sah, Bert-Ram ; Bull, Sacha ; Clerc, Olivier ; Possner, Mathias ; Buechel, Ronny ; Gaemperli, Oliver ; Kaufmann, Philipp

In: The International Journal of Cardiovascular Imaging, 2014, vol. 30, no. 7, p. 1399-1405

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    Titre
    • Coronary artery calcium quantification from contrast enhanced CT using gemstone spectral imaging and material decomposition
    Auteur
    • Fuchs, Tobias. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Stehli, Julia. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Dougoud, Svetlana. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Sah, Bert-Ram. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Bull, Sacha. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Clerc, Olivier. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Possner, Mathias. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Buechel, Ronny. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Gaemperli, Oliver. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    • Kaufmann, Philipp. Cardiac Imaging, Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The International Journal of Cardiovascular Imaging, 2014, vol. 30, no. 7, p. 1399-1405. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325070
    Summary
    To explore the feasibility of coronary artery calcium (CAC) measurement from low-dose contrast enhanced coronary CT angiography (CCTA) as this may obviate the need for an unenhanced CT scan. 52 patients underwent unenhanced cardiac CT and prospectively ECG triggered contrast enhanced CCTA (Discovery HD 750, GE Healthcare, Milwaukee, WI, USA). The latter was acquired in single-source dual-energy mode [gemstone spectral imaging (GSI)]. Virtual unenhanced images were generated from GSI CCTA by monochromatic image reconstruction of 70keV allowing selective iodine material suppression. CAC scores from virtual unenhanced CT were compared to standard unenhanced CT including a linear regression model. After iodine subtraction from the contrast enhanced CCTA the attenuation in the ascending aorta decreased significantly from 359±61 to 54±8HU (P<0.001), the latter comparing well to the value of 64±55HU found in the standard unenhanced CT (P=ns) confirming successful iodine subtraction. After introducing linear regression formula the mean values for Agatston, Volume and Mass scores of virtual unenhanced CT were 187±321, 72±114mm3, and 27±46mg/cm3, comparing well to the values from standard unenhanced CT (187±309, 72±110mm3, and 27±45mg/cm3) yielding an excellent correlation (r=0.96, r=0.96, r=0.92; P<0.001). Mean estimated radiation dose revealed 0.83±0.02mSv from the unenhanced CT and 1.70±0.53mSv from the contrast enhanced CCTA. Single-source dual-energy scanning with GSI allows CAC quantification from low dose contrast enhanced CCTA by virtual iodine contrast subtraction.