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Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival

Mondada, David ; Bosman, Fredrik ; Fontolliet, Charlotte ; Seelentag, Walter

In: Virchows Archiv, 2006, vol. 448, no. 1, p. 35-45

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    Titre
    • Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival
    Auteur
    • Mondada, David. Institute of Pathology, University of Lausanne, Bugnon 25, 1011, Lausanne, Switzerland
    • Bosman, Fredrik. Institute of Pathology, University of Lausanne, Bugnon 25, 1011, Lausanne, Switzerland
    • Fontolliet, Charlotte. Institute of Pathology, University of Lausanne, Bugnon 25, 1011, Lausanne, Switzerland
    • Seelentag, Walter. Institute of Pathology, University of Lausanne, Bugnon 25, 1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:322175
    Summary
    Hepatocyte paraffin 1 (Hep Par 1) and neprilysin (CD10) are well-known markers of hepatocellular carcinoma (HCC). To assess their potential prognostic role, we conducted a retrospective analysis of 97 formalin-fixed and paraffin-embedded HCC from patients treated by surgery with curative intent, using standard immunohistochemical procedures and semiquantitative analysis. Strong Hep Par 1 expression and canalicular CD10 staining pattern were significantly correlated with smaller tumor size (p=0.007 and 0.04, respectively). On univariate analysis, longer overall survival was observed in patients with strong Hep Par 1 expression (p=0.0005) and in patients with a CD10can staining pattern (p=0.02). On multivariate analysis, the combined immunohistochemical score (CIS) obtained by addition of Hep Par 1 and CD10can scores and subtraction of cytoplasmic CD10 score was retained as the single most important prognostic factor (p=0.001). Patients with a CIS <4 had a 3.5-fold increased risk of death, as compared to those with a CIS ≥4. In conclusion, strong Hep Par 1 expression, presence of CD10can labeling, and absence of CD10cyt staining are favorable prognostic factors in HCC, which can be easily combined into a single immunohistochemical score for routine clinical use