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Cardioplegia and ventricular late potentials in cardiac surgical patients

Schütz, N. ; Romand, J. ; Yanez, N. ; Treggiari, M. ; Bendjelid, K.

In: Journal of Clinical Monitoring and Computing, 2011, vol. 25, no. 4, p. 269-274

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    Titre
    • Cardioplegia and ventricular late potentials in cardiac surgical patients
    Auteur
    • Schütz, N.. Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    • Romand, J.. Division of Intensive Care, Department of APSI, Médecin Adjoint Agrégé, Geneva University Hospitals, Intensive Care Unit, Rue Micheli-du-Crest 24, 1205, Geneva, Switzerland
    • Yanez, N.. Department of Biostatistics, University of Washington, Seattle, WA, USA
    • Treggiari, M.. Department of Anaesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA
    • Bendjelid, K.. Division of Intensive Care, Department of APSI, Médecin Adjoint Agrégé, Geneva University Hospitals, Intensive Care Unit, Rue Micheli-du-Crest 24, 1205, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Clinical Monitoring and Computing, 2011, vol. 25, no. 4, p. 269-274. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321511
    Summary
    Background and objective: Ventricular late potentials (LP) recording with signal-averaged electrocar- diogram allow identifying patients at risk of sudden death and ventricular tachycardia. Cardiac surgery with cardiopulmonary bypass (CPB) could predispose to the development of myocardial ischemia related to imperfect cardioplegia. To the best of our knowledge, no study investigated the protection of cardioplegia and CPB regarding the occurrence of LP in patients without previous myocardial infarction and undergoing cardiac surgery. Methods: In 61 elective patients scheduled for cardiac surgery involving CPB, signal-averaged electrocar- diogram was performed the day before and 24-48h after the surgery. The electrodes were positioned according to Frank's orthogonal derivations. Twenty five patients were excluded because of poor quality signals, leaving 36 patients (age, 64 ± 14) available for the analyses. An abnormal signal-averaged electrocardiogram was considered when ≥2 of the recorded indexes were present. McNemar's tests were performed on the dichotomized values to investigate differences in pre-post scores. Results: The mean CPB duration was of 110 ± 57min. Patients scheduled for cardiac surgery do not exhibited LP after CPB (no significant difference in pre-post CPB scores, P=NS). The probability of a patient with a negative score transitioning to a positive score was 0.23 (P=NS). Conclusions: The present study in cardiac surgical patients suggests that cardioplegia associated to CPB has no significant impact on the occurrence of LP, irrespective of surgery performed