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Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid

Eng, Carine ; Simone, Jean-Mary ; Hartenbach, Akane ; Loiseau, François ; Neier, Reinhard

In: Monatshefte für Chemie - Chemical Monthly, 2009, vol. 140, no. 3, p. 349-354

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    Title
    • Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid
    Author
    • Eng, Carine. Department of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, 2007, Neuchâtel, Switzerland
    • Simone, Jean-Mary. Department of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, 2007, Neuchâtel, Switzerland
    • Hartenbach, Akane. Department of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, 2007, Neuchâtel, Switzerland
    • Loiseau, François. Department of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, 2007, Neuchâtel, Switzerland
    • Neier, Reinhard. Department of Chemistry, University of Neuchâtel, Avenue Bellevaux 51, 2007, Neuchâtel, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Monatshefte für Chemie - Chemical Monthly, 2009, vol. 140, no. 3, p. 349-354. Springer Vienna
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:321374
    Summary
    The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our ω-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles. Graphical abstract