Fulltext

Inhibition of the Fenton reaction by nitrogen monoxide

Lu, Changyuan ; Koppenol, Willem

In: JBIC Journal of Biological Inorganic Chemistry, 2005, vol. 10, no. 7, p. 732-738

Ajouter à la liste personnelle
    Titre
    • Inhibition of the Fenton reaction by nitrogen monoxide
    Auteur
    • Lu, Changyuan. Institute of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Hönggerberg, Wolfgang-Pauli-Strasse 10, 8093, Zurich, Switzerland
    • Koppenol, Willem. Institute of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Hönggerberg, Wolfgang-Pauli-Strasse 10, 8093, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • JBIC Journal of Biological Inorganic Chemistry, 2005, vol. 10, no. 7, p. 732-738. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:320855
    Summary
    The toxicity of iron is believed to originate from the Fenton reaction which produces the hydroxyl radical and/or oxoiron(2+). The effect of nitrogen monoxide on the kinetics of the reaction of iron(II) bound to citrate, ethylenediamine-N,N′-diacetate (edda), ethylenediamine-N,N,N′,N′-tetraacetate (edta), (N-hydroxyethyl)amine-N,N′,N′-triacetate (hedta), and nitrilotriacetate (nta) with hydrogen peroxide was studied by stopped-flow spectrophotometry. Nitrogen monoxide inhibits the Fenton reaction to a large extent. For instance, hydrogen peroxide oxidizes iron(II) citrate with a rate constant of 5.8×103M−1s−1, but in the presence of nitrogen monoxide, the rate constant is 2.9×102M−1s−1 . Similar to hydrogen peroxide, the reaction of tert-butyl hydroperoxide with iron(II) complexes is also efficiently inhibited by nitrogen monoxide. Generally, nitrogen monoxide binds rapidly to a coordination site of iron(II) occupied by water. The rate of oxidation is influenced by the rate of dissociation of the nitrogen monoxide from iron(II)