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Gout in pediatric renal transplant recipients

Trück, Johannes ; Laube, Guido ; von Vigier, Rodo ; Goetschel, Philippe

In: Pediatric Nephrology, 2010, vol. 25, no. 12, p. 2535-2538

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    Titre
    • Gout in pediatric renal transplant recipients
    Auteur
    • Trück, Johannes. Department of Pediatrics, Triemli Hospital Zurich, Birmensdorferstrasse 497, 8063, Zurich, Switzerland
    • Laube, Guido. Nephrology Unit, University Children's Hospital Zurich, Zurich, Switzerland
    • von Vigier, Rodo. Pediatric Nephrology, University Children's Hospital Bern Inselspital, Bern, Switzerland
    • Goetschel, Philippe. Department of Pediatrics, Triemli Hospital Zurich, Birmensdorferstrasse 497, 8063, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:320673
    Summary
    Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7-8.5 years following RTx. Since receiving allopurinol, all patients had been free of gouty symptoms. To prevent severe bone marrow depletion, the dosage of azathioprine, an immunosupressant drug, was reduced by 50% to prevent interaction with allopurinol. Because atypical presentation of gout can occur, a high index of suspicion is needed to allow appropriate diagnosis of this disease in patients with skeletal pain after RTx