Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
Scalfaro, P. ; Chesaux, J. ; Buchwalder, P. ; Biollaz, J. ; Micheli, J.
In: Intensive Care Medicine, 1998, vol. 24, no. 3, p. 247-250
Ajouter à la liste personnelle- Summary
- Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood