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Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment

Scalfaro, P. ; Chesaux, J. ; Buchwalder, P. ; Biollaz, J. ; Micheli, J.

In: Intensive Care Medicine, 1998, vol. 24, no. 3, p. 247-250

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    Titel
    • Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
    Autor
    • Scalfaro, P.. Division of Neonatology, University Hospital, CH-1011, Lausanne, Switzerland
    • Chesaux, J.. Department of Paediatrics, University Hospital, CH-1011, Lausanne, Switzerland
    • Buchwalder, P.. Division of Clinical Pharmacology, University Hospital, CH-1011, Lausanne, Switzerland
    • Biollaz, J.. Division of Clinical Pharmacology, University Hospital, CH-1011, Lausanne, Switzerland
    • Micheli, J.. Division of Neonatology, University Hospital, CH-1011, Lausanne, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Intensive Care Medicine, 1998, vol. 24, no. 3, p. 247-250. Springer-Verlag
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:320257
    Summary
    Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood