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Low-dose intra-arterial contrast-enhanced MR aortography in patients based on a theoretically derived injection protocol

Potthast, S. ; Schulte, A.-C ; Bongartz, G. ; Hügli, R. ; Aschwanden, M. ; Bilecen, D.

In: European Radiology, 2005, vol. 15, no. 11, p. 2347-2353

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    Titre
    • Low-dose intra-arterial contrast-enhanced MR aortography in patients based on a theoretically derived injection protocol
    Auteur
    • Potthast, S.. Department of Diagnostic Radiology, University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Schulte, A.-C. Biocenter, University of Basel, Klingelbergstrasse 50/70, 4056, Basel, Switzerland
    • Bongartz, G.. Department of Diagnostic Radiology, University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Hügli, R.. Department of Diagnostic Radiology, University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Aschwanden, M.. Department of Angiology, University of Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Bilecen, D.. Department of Diagnostic Radiology, University Hospital of Basel, Petersgraben 4, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Radiology, 2005, vol. 15, no. 11, p. 2347-2353. Springer-Verlag; http://www.springer.de
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319559
    Summary
    Multiple intra-arterial contrast agent injections are necessary during MR-guided endovascular interventions. In respect to the approved limits of maximum daily gadolinium dose, a low-dose injection protocol is mandatory. The objective of this study was to derive and apply a low-dose injection protocol for intra-arterial 3D contrast-enhanced MR aortography in patients. Injection rate (Qinj), concentration of injected gadolinium [Gd]inj and aortal blood flow rate (Qblood) were included for the theoretical evaluation of signal intensity (SI) of the arterial lumen. SI simulations were carried out at Qinj=2 versus 4ml/s in the [Gd]inj range between 0-500mM. Qinj and [Gd]inj with SI above the 75% threshold of the maximal SI were regarded as optimal injection parameters. [Gd]inj=50mM and Qinj=4ml/s were considered as optimal and were administered in five patients for 3D MR aortography. All images revealed clear delineation of the abdominal aorta and its major branches. Mean±SD of contrast-to-noise ratios of the abdominal aorta, common iliac and renal artery were 70.2±15.2, 58.6±12.3 and 67.4±12.3. Approximately seven intra-aortal injections would be permissible in patients during MR-guided interventions without exceeding the maximal dose of gadolinium