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Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children

Merlini, Laura ; Borzani, Irene ; Anooshiravani, Mehrak ; Rochat, Isabelle ; Ozsahin, Ayse ; Hanquinet, Sylviane

In: Pediatric Radiology, 2008, vol. 38, no. 11, p. 1201-1209

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    Titre
    • Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children
    Auteur
    • Merlini, Laura. Paediatric Radiology Unit, University of Geneva Children's Hospital, Rue Willy-Donzé 6, 1205, Geneva, Switzerland
    • Borzani, Irene. Paediatric Radiology Unit, University of Geneva Children's Hospital, Rue Willy-Donzé 6, 1205, Geneva, Switzerland
    • Anooshiravani, Mehrak. Paediatric Radiology Unit, University of Geneva Children's Hospital, Rue Willy-Donzé 6, 1205, Geneva, Switzerland
    • Rochat, Isabelle. Paediatric Pneumology Unit, University of Geneva Children's Hospital, Geneva, Switzerland
    • Ozsahin, Ayse. Paediatric Oncology Unit, University of Geneva Children's Hospital, Geneva, Switzerland
    • Hanquinet, Sylviane. Paediatric Radiology Unit, University of Geneva Children's Hospital, Rue Willy-Donzé 6, 1205, Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319165
    Summary
    Background: Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established. Objective: To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation with chronic GVHD (cGVHD). Materials and methods: A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3months after BMT (16 allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and with the severity of cGVHD. Results: Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on HRCT and severe cGVHD (P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities on HRCT. Conclusion: The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation of the disease. HRCT is a useful tool when combined with clinical data