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The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise

Vaughan, David ; Huber-Abel, Felicitas ; Graber, Franziska ; Hoppeler, Hans ; Flück, Martin

In: European Journal of Applied Physiology, 2013, vol. 113, no. 7, p. 1719-1729

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    Titre
    • The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise
    Auteur
    • Vaughan, David. Institute for Biomedical Research into Human Movement and Health, School of HealthCare Science, Manchester Metropolitan University, Chester Street, M1 5GD, Manchester, UK
    • Huber-Abel, Felicitas. Department of Anatomy, University of Berne, Berne, Switzerland
    • Graber, Franziska. Department of Anatomy, University of Berne, Berne, Switzerland
    • Hoppeler, Hans. Department of Anatomy, University of Berne, Berne, Switzerland
    • Flück, Martin. Institute for Biomedical Research into Human Movement and Health, School of HealthCare Science, Manchester Metropolitan University, Chester Street, M1 5GD, Manchester, UK
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Applied Physiology, 2013, vol. 113, no. 7, p. 1719-1729. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317456
    Summary
    The presence of a silencing sequence (the I-allele) in the gene for the upstream regulator of blood flow, angiotensin I-converting enzyme (ACE), is associated with superior endurance performance and its trainability. We tested in a retrospective study with 36 Caucasian men of Swiss descent whether carriers of the ACE I-allele demonstrate a modified adaptive response of energy supply lines in knee extensor muscle, and aerobic fitness, to endurance training based on 6weeks of supervised bicycle exercise or 6months of self-regulated running (p value