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Anticoagulation for radiation-induced neurotoxicity revisited

Happold, Caroline ; Ernemann, Ulrike ; Roth, Patrick ; Wick, Wolfgang ; Weller, Michael ; Schmidt, Friederike

In: Journal of Neuro-Oncology, 2008, vol. 90, no. 3, p. 357-362

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    Titre
    • Anticoagulation for radiation-induced neurotoxicity revisited
    Auteur
    • Happold, Caroline. Department of General Neurology, Hertie Institute for Brain Research, Tubingen, Germany
    • Ernemann, Ulrike. Department of Neuroradiology, University of Tübingen Medical School, Tubingen, Germany
    • Roth, Patrick. Department of General Neurology, Hertie Institute for Brain Research, Tubingen, Germany
    • Wick, Wolfgang. Department of General Neurology, Hertie Institute for Brain Research, Tubingen, Germany
    • Weller, Michael. Department of General Neurology, Hertie Institute for Brain Research, Tubingen, Germany
    • Schmidt, Friederike. Department of General Neurology, Hertie Institute for Brain Research, Tubingen, Germany
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Neuro-Oncology, 2008, vol. 90, no. 3, p. 357-362. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317156
    Summary
    No effective treatment for delayed radiation-induced neurotoxicity has been established. Its natural course is highly variable, but spontaneous recovery has been well documented. Here we report our experience with therapeutic anticoagulation in patients with cerebral lesions (n=3), cranial nerve lesions (n=1) or myelopathy (n=4) attributed to irradiation. Two of three patients with cerebral lesions and the patient with cranial nerve lesions showed a minor improvement of clinical symptoms. In contrast, none of the patients with radiation myelopathy improved. No patient suffered hemorrhage or other adverse effects of anticoagulation. Overall, anticoagulation therapy demonstrates only modest activity for delayed radiation-induced neurotoxicity in this small case series