Fulltext

On pseudo-values for regression analysis in competing risks models

Graw, Frederik ; Gerds, Thomas ; Schumacher, Martin

In: Lifetime Data Analysis, 2009, vol. 15, no. 2, p. 241-255

Ajouter à la liste personnelle
    Titre
    • On pseudo-values for regression analysis in competing risks models
    Auteur
    • Graw, Frederik. Institute of Integrative Biology, ETH Zurich, Universitätsstr. 16, 8092, Zurich, Switzerland
    • Gerds, Thomas. Department of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, 1014, Copenhagen K, Denmark
    • Schumacher, Martin. Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Lifetime Data Analysis, 2009, vol. 15, no. 2, p. 241-255. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317022
    Summary
    For regression on state and transition probabilities in multi-state models Andersen et al. (Biometrika 90:15-27, 2003) propose a technique based on jackknife pseudo-values. In this article we analyze the pseudo-values suggested for competing risks models and prove some conjectures regarding their asymptotics (Klein and Andersen, Biometrics 61:223-229, 2005). The key is a second order von Mises expansion of the Aalen-Johansen estimator which yields an appropriate representation of the pseudo-values. The method is illustrated with data from a clinical study on total joint replacement. In the application we consider for comparison the estimates obtained with the Fine and Gray approach (J Am Stat Assoc 94:496-509, 1999) and also time-dependent solutions of pseudo-value regression equations