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The causes of Charcot-Marie-Tooth disease

Young, P. ; Suter, U.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 12, p. 2547-2560

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    Titre
    • The causes of Charcot-Marie-Tooth disease
    Auteur
    • Young, P.. Department of Neurology, University of Münster, Münster, Germany
    • Suter, U.. Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Hönggerberg, Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 12, p. 2547-2560. Birkhäuser-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316970
    Summary
    Charcot-Marie-Tooth (CMT) disease serves as the summary term for the most frequent forms of inherited peripheral neuropathies that affect motor and sensory nerves. In the last 12 years, 14 genes have been identified that cause different CMT subforms. The genes found initially are predominantly responsible for demyelinating and dysmyelinating neuropathies. Genes affected in axonal and rare forms of CMT have only recently been identified. In this review, we will focus on the currently known genes that are associated with CMT syndromes with regards to their genetics and function