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Adult neurogenesis in the mammalian brain

Braun, Simon ; Jessberger, Sebastian

In: Frontiers in Biology, 2013, vol. 8, no. 3, p. 295-304

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    Titre
    • Adult neurogenesis in the mammalian brain
    Auteur
    • Braun, Simon. Brain Research Institute, Faculty of Medicine, University of Zurich, 8057, Zurich, Switzerland
    • Jessberger, Sebastian. Brain Research Institute, Faculty of Medicine, University of Zurich, 8057, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Frontiers in Biology, 2013, vol. 8, no. 3, p. 295-304. SP Higher Education Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316712
    Summary
    New neurons are generated throughout life in distinct areas of the mammalian brain. This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. Here, we review the current knowledge regarding the fate and potency of neural stem cells (NSCs), as well as the mechanisms underlying neuronal differentiation and subsequent integration. Furthermore, we discuss the functional significance of adult neurogenesis in health and disease, and offer brief insight into the future directions of the adult neurogenesis field