Fulltext

Left ventricular dyssynchrony assessment by phase analysis from gated PET-FDG scans

Pazhenkottil, Aju ; Buechel, Ronny ; Nkoulou, Rene ; Ghadri, Jelena-Rima ; Herzog, Bernhard ; Husmann, Lars ; Wolfrum, Mathias ; Küest, Silke ; Fiechter, Michael ; Gaemperli, Oliver ; Kaufmann, Philipp

In: Journal of Nuclear Cardiology, 2011, vol. 18, no. 5, p. 920-925

Ajouter à la liste personnelle
    Titre
    • Left ventricular dyssynchrony assessment by phase analysis from gated PET-FDG scans
    Auteur
    • Pazhenkottil, Aju. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Buechel, Ronny. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Nkoulou, Rene. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Ghadri, Jelena-Rima. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Herzog, Bernhard. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Husmann, Lars. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Wolfrum, Mathias. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Küest, Silke. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Fiechter, Michael. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Gaemperli, Oliver. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Kaufmann, Philipp. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Nuclear Cardiology, 2011, vol. 18, no. 5, p. 920-925. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316478
    Summary
    Background: The outcome of patients with severe ischaemic left ventricular (LV) dysfunction is determined by the extent of myocardial viability and the presence of LV dyssynchrony. We aimed at assessing both parameters from the same imaging method, i.e. gated positron emission tomography (PET) F18-fluorodeoxyglucose (FDG) scans. Methods: Phase analysis from Emory Cardiac Toolbox was applied on gated PET-FDG scans to assess histogram bandwidth and standard deviation (SD) as a measure of LV dyssynchrony in 30 heart failure patients (mean ejection fraction: 30.2%±13.8%) referred for the evaluation of myocardial viability. Cut-off values from single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) best predicting cardiac resynchronization therapy (CRT) response served as standard of reference (bandwidth<135°; phase SD<43°). Severe LV dyssynchrony was diagnosed if both SPECT-MPI values were above these limits. Intraclass correlation and clinical agreement in detection of severe LV dyssynchrony by PET vs SPECT were assessed. Results: There was a significant correlation between PET-FDG and SPECT-MPI for bandwidth (r=0.88, P<.001) and phase SD (r=0.88, P<.001) resulting in an excellent clinical agreement between the two methods of 93%. Conclusions: Accurate LV dyssynchrony assessment by phase analysis of gated PET-FDG scans is feasible, allowing assessing myocardial viability and severe LV dyssynchrony in one scan