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Double-network acrylamide hydrogel compositions adapted to achieve cartilage-like dynamic stiffness

Ronken, S. ; Wirz, D. ; Daniels, A. ; Kurokawa, T. ; Gong, J. ; Arnold, M.

In: Biomechanics and Modeling in Mechanobiology, 2013, vol. 12, no. 2, p. 243-248

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    Titre
    • Double-network acrylamide hydrogel compositions adapted to achieve cartilage-like dynamic stiffness
    Auteur
    • Ronken, S.. Laboratory of Biomechanics and Biocalorimetry (LOB2), Biozentrum/Pharmazentrum, Faculty of Medicine, University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland
    • Wirz, D.. Laboratory of Biomechanics and Biocalorimetry (LOB2), Biozentrum/Pharmazentrum, Faculty of Medicine, University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland
    • Daniels, A.. Laboratory of Biomechanics and Biocalorimetry (LOB2), Biozentrum/Pharmazentrum, Faculty of Medicine, University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland
    • Kurokawa, T.. Department of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    • Gong, J.. Department of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    • Arnold, M.. Department of Orthopedic Surgery and Skeletal Traumatology, Kantonsspital Bruderholz, 4101, Bruderholz, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Biomechanics and Modeling in Mechanobiology, 2013, vol. 12, no. 2, p. 243-248. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:316047
    Summary
    Since articular cartilage has a limited potential for spontaneous healing, various techniques are employed to repair cartilage lesions. Acrylate-based double-network (DN) hydrogels containing ~90% water have shown promising properties as repair materials for skeletal system soft tissues. Although their mechanical properties approach those of native cartilage, the critical factor—stiffness—of DN-gels does not equal the stiffness of articular cartilage. This study investigated whether revised PAMPS/PAAm compositions with lower water content result in stiffness parameters closer to cartilage. DN-gels containing 61, 86 and 90% water were evaluated using two non-destructive, mm-scale indentation test modes: fast-impact (FI) and slow-sinusoidal (SS) deformation. Deformation resistance (dynamic modulus) and energy handling (loss angle) were determined. The dynamic modulus increased with decreasing water content in both testing modes. In the 61% water DN-gel, the modulus resembled that of cartilage (FI-mode: DN-gel = 12, cartilage = 17; SS-mode: DN-gel = 4, cartilage = 1.7MPa). Loss angle increased with decreasing water content in fast-impact, but not in slow-sinusoidal deformation. However, loss angle was still much lower than cartilage (FI: DN-gel = 5, cartilage = 11; SS: DN-gel = 10, cartilage = 32°), indicating somewhat less ability to dissipate energy. Overall, results show that it is possible to adapt DN-gel composition to produce dynamic stiffness properties close to normal articular cartilage