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Treatment of Resistant Fever: New Method of Local Cerebral Cooling

Mink, Susanne ; Schwarz, Urs ; Mudra, Regina ; Gugl, Christoph ; Fröhlich, Jürg ; Keller, Emanuela

In: Neurocritical Care, 2011, vol. 15, no. 1, p. 107-112

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    Titre
    • Treatment of Resistant Fever: New Method of Local Cerebral Cooling
    Auteur
    • Mink, Susanne. Department of Neurosurgery, Neuroscience Intensive Care Unit, University Hospital of Zurich, Zurich, Switzerland
    • Schwarz, Urs. Department of Neurology, University Hospital of Zurich, Zurich, Switzerland
    • Mudra, Regina. Institute of Biomedical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland
    • Gugl, Christoph. Institute of Biomedical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland
    • Fröhlich, Jürg. Laboratory for Electromagnetic Fields and Microwave Electronics, Swiss Federal Institute of Technology, Zurich, Switzerland
    • Keller, Emanuela. Department of Neurosurgery, Neuroscience Intensive Care Unit, University Hospital of Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315705
    Summary
    Background: Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever. Methods: Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour8. Results: The brain, blood, and urinary bladder temperatures decreased significantly from hour0 to a minimum in hour5 (P<0.01). After hour5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted. Conclusion: This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patients