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Optimization of cardiac cine in the rat on a clinical 1.5-T MR system

Montet-Abou, K. ; Daire, J. ; Ivancevic, M. ; Hyacinthe, J. ; Nguyen, D. ; Jorge-Costa, M. ; Morel, D. ; Vallée, J.

In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2006, vol. 19, no. 3, p. 144-151

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    Titre
    • Optimization of cardiac cine in the rat on a clinical 1.5-T MR system
    Auteur
    • Montet-Abou, K.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Daire, J.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Ivancevic, M.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Hyacinthe, J.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Nguyen, D.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Jorge-Costa, M.. Anesthesiology, Pharmacology and Intensive Care in Surgery Department, Anesthesiological Investigations Unit, Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Morel, D.. Anesthesiology, Pharmacology and Intensive Care in Surgery Department, Anesthesiological Investigations Unit, Geneva University Hospital, 1211, Geneva 14, Switzerland
    • Vallée, J.. Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211, Geneva 14, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Magnetic Resonance Materials in Physics, Biology and Medicine, 2006, vol. 19, no. 3, p. 144-151. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315576
    Summary
    Object: the overall goal was to study cardiovascular function in small animals using a clinical 1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and temporal resolution. Materials and methods: normal rat hearts (n = 9) were imaged using a 1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners) sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners) sequences with different in-plane resolution, and with and without flow compensation and half-Fourier acquisition. The hearts of four rats were then excised and left-ventricle mass was weighed. Inter- and intra-observer variability analysis was performed for magnetic resonance imaging (MRI) measurements. Results: half-Fourier acquisition with flow compensation gave the best sequence in terms of image quality, spatial as well as temporal resolution, and suppression of flow artifact. Ejection fraction was 71 ± 4% with less than 5% inter- and intra-observer variability. A good correlation was found between MRI-calculated left-ventricular mass and wet weight. Conclusions: using optimized sequences on a clinical 1.5-T MR scanner can provide accurate quantification of cardiac function in small animals and can promote cardiovascular research on small animals at 1.5-T