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Systematic Review of Delayed Postoperative Hemorrhage after Pancreatic Resection

Roulin, Didier ; Cerantola, Yannick ; Demartines, Nicolas ; Schäfer, Markus

In: Journal of Gastrointestinal Surgery, 2011, vol. 15, no. 6, p. 1055-1062

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    Titre
    • Systematic Review of Delayed Postoperative Hemorrhage after Pancreatic Resection
    Auteur
    • Roulin, Didier. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
    • Cerantola, Yannick. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
    • Demartines, Nicolas. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
    • Schäfer, Markus. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Gastrointestinal Surgery, 2011, vol. 15, no. 6, p. 1055-1062. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:315203
    Summary
    Introduction: This review assesses the presentation, management, and outcome of delayed postpancreatectomy hemorrhage (PPH) and suggests a novel algorithm as possible standard of care. Methods: An electronic search of Medline and Embase databases from January 1990 to February 2010 was undertaken. A random-effect meta-analysis for success rate and mortality of laparotomy vs. interventional radiology after delayed PPH was performed. Results: Fifteen studies comprising of 248 patients with delayed PPH were included. Its incidence was of 3.3%. A sentinel bleed heralding a delayed PPH was observed in 45% of cases. Pancreatic leaks or intraabdominal abscesses were found in 62%. Interventional radiology was attempted in 41%, and laparotomy was undertaken in 49%. On meta-analysis comparing laparotomy vs. interventional radiology, no significant difference could be found in terms of complete hemostasis (76% vs. 80%; P = 0.35). A statistically significant difference favored interventional radiology vs. laparotomy in term of mortality (22% vs. 47%; P = 0.02). Conclusions: Proper management of postoperative complications, such as pancreatic leak and intraabdominal abscess, minimizes the risk of delayed PPH. Sentinel bleeding needs to be thoroughly investigated. If a pseudoaneurysm is detected, it has to be treated by interventional angiography, in order to prevent a further delayed PPH. Early angiography and embolization or stenting is safe and should be the procedure of choice. Surgery remains a therapeutic option if no interventional radiology is available, or patients cannot be resuscitated for an interventional treatment