Fulltext

Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia

Held, Kathrin ; Eiglmeier, Ingrid ; Himmelein, Susanne ; Sinicina, Inga ; Brandt, Thomas ; Theil, Diethilde ; Dornmair, Klaus ; Derfuss, Tobias

In: Journal of NeuroVirology, 2012, vol. 18, no. 1, p. 62-68

Ajouter à la liste personnelle
    Titre
    • Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia
    Auteur
    • Held, Kathrin. Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377, Munich, Germany
    • Eiglmeier, Ingrid. Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377, Munich, Germany
    • Himmelein, Susanne. IFB, Ludwig Maximilian University, 81377, Munich, Germany
    • Sinicina, Inga. Department of Legal Medicine, Ludwig Maximilian University, 80336, Munich, Germany
    • Brandt, Thomas. Department of Clinical Neurosciences, Ludwig Maximilian University, 81377, Munich, Germany
    • Theil, Diethilde. Department of Clinical Neurosciences, Ludwig Maximilian University, 81377, Munich, Germany
    • Dornmair, Klaus. Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377, Munich, Germany
    • Derfuss, Tobias. Department of Neurology/Department of Biomedicine, University of Basel, Petersgraben 4, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of NeuroVirology, 2012, vol. 18, no. 1, p. 62-68. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:314667
    Summary
    Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides