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Xanthines as a scaffold for molecular diversity

Heizmann, Gerhard ; Eberle, Alex

In: Molecular Diversity, 1997, vol. 2, no. 3, p. 171-174

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    Titre
    • Xanthines as a scaffold for molecular diversity
    Auteur
    • Heizmann, Gerhard. Laboratory of Endocrinology, Department of Research (ZLF), University Hospital and University Children's Hospital Basel, CH-4031, Basel, Switzerland
    • Eberle, Alex. Laboratory of Endocrinology, Department of Research (ZLF), University Hospital and University Children's Hospital Basel, CH-4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Molecular Diversity, 1997, vol. 2, no. 3, p. 171-174. Kluwer Academic Publishers
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:314228
    Summary
    Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring closure reaction by condensation of a nitroso function with an activated methylene group. The selected reaction sequence allows the production of a highly diverse small-molecule combinatorial compound library