Xanthines as a scaffold for molecular diversity
Heizmann, Gerhard ; Eberle, Alex
In: Molecular Diversity, 1997, vol. 2, no. 3, p. 171-174
Ajouter à la liste personnelle- Summary
- Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring closure reaction by condensation of a nitroso function with an activated methylene group. The selected reaction sequence allows the production of a highly diverse small-molecule combinatorial compound library