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Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Goede, Jeroen ; Misselwitz, Benjamin ; Taverna, Christian ; Schanz, Urs ; Dispenzieri, Angela ; Hummel, Yvonne ; Trüeb, Ralph ; Fehr, Jörg

In: Annals of Hematology, 2007, vol. 86, no. 4, p. 303-306

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    Titre
    • Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation
    Auteur
    • Goede, Jeroen. Clinic of Hematology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Misselwitz, Benjamin. Clinic of Hematology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Taverna, Christian. Clinic for Internal Medicine, Kantonsspital Münsterlingen, Münsterlingen, Switzerland
    • Schanz, Urs. Clinic of Hematology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Dispenzieri, Angela. Division of Hematology, Mayo Clinic, Rochester, USA
    • Hummel, Yvonne. Clinic for Oncology and Hematology, City Hospital Triemli, Zürich, Switzerland
    • Trüeb, Ralph. Department of Dermatology, University Hospital Zürich, Zürich, Switzerland
    • Fehr, Jörg. Clinic of Hematology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:313810
    Summary
    Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma