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Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

Place, Nicolas ; Yamada, Takashi ; Bruton, Joseph ; Westerblad, Håkan

In: European Journal of Applied Physiology, 2010, vol. 110, no. 1, p. 1-15

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    Titre
    • Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
    Auteur
    • Place, Nicolas. Institute of Movement Sciences and Sport Medicine, Faculté de Médecine, Université de Genève, Rue du conseil général 10, 1205, Genève, Switzerland
    • Yamada, Takashi. Department of Physiology and Pharmacology, Karolinska Institute, von Eulers väg 8, 171 77, Stockholm, Sweden
    • Bruton, Joseph. Department of Physiology and Pharmacology, Karolinska Institute, von Eulers väg 8, 171 77, Stockholm, Sweden
    • Westerblad, Håkan. Department of Physiology and Pharmacology, Karolinska Institute, von Eulers väg 8, 171 77, Stockholm, Sweden
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Applied Physiology, 2010, vol. 110, no. 1, p. 1-15. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:311655
    Summary
    Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca2+ handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise