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Topical Iontophoresis of Valaciclovir Hydrochloride Improves Cutaneous Aciclovir Delivery

Abla, Nada ; Naik, Aarti ; Guy, Richard ; Kalia, Yogeshvar

In: Pharmaceutical Research, 2006, vol. 23, no. 8, p. 1842-1849

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    Titre
    • Topical Iontophoresis of Valaciclovir Hydrochloride Improves Cutaneous Aciclovir Delivery
    Auteur
    • Abla, Nada. School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1211, Geneva, Switzerland
    • Naik, Aarti. School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1211, Geneva, Switzerland
    • Guy, Richard. School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1211, Geneva, Switzerland
    • Kalia, Yogeshvar. School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1211, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Pharmaceutical Research, 2006, vol. 23, no. 8, p. 1842-1849. Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:311369
    Summary
    Purpose: To investigate the topical iontophoresis of valaciclovir (VCV) as a means to improve cutaneous aciclovir (ACV) delivery. Methods: ACV and VCV electrotransport experiments were conducted using excised porcine skin in vitro. Results: While the charged nature of the prodrug, VCV, enabled it to be more efficiently iontophoresed into the skin than the parent molecule, ACV, only the latter was detectable in the receptor chamber, suggesting that VCV was enzymatically cleaved into the active metabolite during skin transit. Iontophoresis of VCV was significantly more efficient than that of ACV; the cumulative permeation of ACV after 1, 2 and 3h of VCV iontophoresis at 0.5mA cm−2 and using an aqueous 2mM (∼0.06%) formulation was 20 ± 10, 104 ± 47 and 194 ± 82μg cm−2, respectively (cf. non-quantifiable levels, 0.1 and 1.0 ± 0.7μg cm−2 after ACV iontophoresis). Conclusions: These delivery rates provide ample room to reduce either current density or the duration of current application. Preliminary in vitro data serve to emphasize the potential of VCV iontophoresis to improve the topical therapy of cutaneous herpes simplex infections and merit further investigation to demonstrate clinical efficacy