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[11C]acetate PET/CT Visualizes Skeletal Muscle Exercise Participation, Impaired Function, and Recovery after Hip Arthroplasty; First Results

Buchegger, Franz ; Ratib, Osman ; Willi, Jean-Pierre ; Steiner, Charles ; Seimbille, Yann ; Zaidi, Habib ; Graf, Véronique ; Peter, Robin ; Jung, Maximilien

In: Molecular Imaging and Biology, 2011, vol. 13, no. 4, p. 793-799

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    Titre
    • [11C]acetate PET/CT Visualizes Skeletal Muscle Exercise Participation, Impaired Function, and Recovery after Hip Arthroplasty; First Results
    Auteur
    • Buchegger, Franz. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Ratib, Osman. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Willi, Jean-Pierre. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Steiner, Charles. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Seimbille, Yann. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Zaidi, Habib. Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211, Geneva 14, Switzerland
    • Graf, Véronique. Service of Orthopedic Surgery, University Hospital of Geneva, Geneva, Switzerland
    • Peter, Robin. Service of Orthopedic Surgery, University Hospital of Geneva, Geneva, Switzerland
    • Jung, Maximilien. Service of Orthopedic Surgery, University Hospital of Geneva, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Molecular Imaging and Biology, 2011, vol. 13, no. 4, p. 793-799. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:311348
    Summary
    Purpose: Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [11C]acetate PET. Procedures: Two male patients were investigated 3 and 12weeks after hip arthroplasty with muscle [11C]acetate PET/CT performed at rest and exercise. Median muscle SUVmean were calculated on three non-consecutive transverse PET slices. Results: The four exercise PET/CT showed, compared with rest, consistent increase in [11C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12weeks after surgery, but four muscles showed only minor activity increase at 3weeks. At 3months, functional recovery of the latter four muscles was observed. Conclusion: Consistent increase in [11C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3weeks after surgery recovered at 3months. These first observations merit further investigation