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Ca2+ signaling by T-type Ca2+ channels in neurons

Cueni, Lucius ; Canepari, Marco ; Adelman, John ; Lüthi, Anita

In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 457, no. 5, p. 1161-1172

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    Titre
    • Ca2+ signaling by T-type Ca2+ channels in neurons
    Auteur
    • Cueni, Lucius. Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland
    • Canepari, Marco. Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland
    • Adelman, John. Vollum Institute, OHSU, 97239, Portland, OR, USA
    • Lüthi, Anita. Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, CH-1005, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Pflügers Archiv - European Journal of Physiology, 2009, vol. 457, no. 5, p. 1161-1172. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:310656
    Summary
    Among the major families of voltage-gated Ca2+ channels, the low-voltage-activated channels formed by the Cav3 subunits, referred to as T-type Ca2+ channels, have recently gained increased interest in terms of the intracellular Ca2+ signals generated upon their activation. Here, we provide an overview of recent reports documenting that T-type Ca2+ channels act as an important Ca2+ source in a wide range of neuronal cell types. The work is focused on T-type Ca2+ channels in neurons, but refers to non-neuronal cells in cases where exemplary functions for Ca2+ entering through T-type Ca2+ channels have been described. Notably, Ca2+ influx through T-type Ca2+ channels is the predominant Ca2+ source in several neuronal cell types and carries out specific signaling roles. We also emphasize that Ca2+ signaling through T-type Ca2+ channels occurs often in select subcellular compartments, is mediated through strategically co-localized targets, and is exploited for unique physiological functions