Fulltext

Mutation position and type of substitution in the β-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis

Bodmer, Thomas ; Zürcher, Gabriela ; Imboden, Paul ; Telenti, Amalio

In: Journal of Antimicrobial Chemotherapy, 1995, vol. 35, no. 2, p. 345-348

Add to personal list
    Title
    • Mutation position and type of substitution in the β-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis
    Author
    • Bodmer, Thomas. Institute for Medical Microbiology, University of Berne, CH-3010 Bern, Switzerland
    • Zürcher, Gabriela. Institute for Medical Microbiology, University of Berne, CH-3010 Bern, Switzerland
    • Imboden, Paul. Institute for Medical Microbiology, University of Berne, CH-3010 Bern, Switzerland
    • Telenti, Amalio. Institute for Medical Microbiology, University of Berne, CH-3010 Bern, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Antimicrobial Chemotherapy, 1995, vol. 35, no. 2, p. 345-348. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:304833
    Summary
    Quantitative susceptibility testing for rifampicin, rifabutin and rifapentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase β-subunit (rpoB)revealed that both mutation position and type of amino acid substitution influence the in-vitro activity of rifamycins in rifampicin-resistant strains