Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Rotger, Margalida ; Glass, Tracy R. ; Junier, Thomas ; Lundgren, Jens ; Neaton, James D. ; Poloni, Estella S. ; van 't Wout, Angélique B. ; Lubomirov, Rubin ; Colombo, Sara ; Martinez, Raquel ; Rauch, Andri ; Günthard, Huldrych F. ; Neuhaus, Jacqueline ; Wentworth, Deborah ; van Manen, Danielle ; Gras, Luuk A. ; Schuitemaker, Hanneke ; Albini, Laura ; Torti, Carlo ; Jacobson, Lisa P. ; Li, Xiuhong ; Kingsley, Lawrence A. ; Carli, Federica ; Guaraldi, Giovanni ; Ford, Emily S. ; Sereti, Irini ; Hadigan, Colleen ; Martinez, Esteban ; Arnedo, Mireia ; Egaña-Gorroño, Lander ; Gatell, Jose M. ; Law, Matthew ; Bendall, Courtney ; Petoumenos, Kathy ; Rockstroh, Jürgen ; Wasmuth, Jan-Christian ; Kabamba, Kabeya ; Delforge, Marc ; De Wit, Stephane ; Berger, Florian ; Mauss, Stefan ; de Paz Sierra, Mariana ; Losso, Marcelo ; Belloso, Waldo H. ; Leyes, Maria ; Campins, Antoni ; Mondi, Annalisa ; De Luca, Andrea ; Bernardino, Ignacio ; Barriuso-Iglesias, Mónica ; Torrecilla-Rodriguez, Ana ; Gonzalez-Garcia, Juan ; Arribas, José R. ; Fanti, Iuri ; Gel, Silvia ; Puig, Jordi ; Negredo, Eugenia ; Gutierrez, Mar ; Domingo, Pere ; Fischer, Julia ; Fätkenheuer, Gerd ; Alonso-Villaverde, Carlos ; Macken, Alan ; Woo, James ; McGinty, Tara ; Mallon, Patrick ; Mangili, Alexandra ; Skinner, Sally ; Wanke, Christine A. ; Reiss, Peter ; Weber, Rainer ; Bucher, Heiner C. ; Fellay, Jacques ; Telenti, Amalio ; Tarr, Philip E.

In: Clinical Infectious Diseases, 2013, vol. 57, no. 1, p. 112-121

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    Summary
    We show in human immunodeficiency virus-positive persons that the coronary artery disease effect of an unfavorable genetic background is comparable to previous studies in the general population, and comparable in size to traditional risk factors and antiretroviral regimens known to increase cardiovascular risk