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Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients

Hecht, M. ; Zimmer, L. ; Loquai, C. ; Weishaupt, C. ; Gutzmer, R. ; Schuster, B. ; Gleisner, S. ; Schulze, B. ; Goldinger, S. M. ; Berking, C. ; Forschner, A. ; Clemens, P. ; Grabenbauer, G. ; Müller-Brenne, T. ; Bauch, J. ; Eich, H. T. ; Grabbe, S. ; Schadendorf, D. ; Schuler, G. ; Keikavoussi, P. ; Semrau, S. ; Fietkau, R. ; Distel, L. V. ; Heinzerling, L.

In: Annals of Oncology, 2015, vol. 26, no. 6, p. 1238-1244

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    Titre
    • Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients
    Auteur
    • Hecht, M.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Zimmer, L.. Department of Dermatology, University Hospital Essen, Essen
    • Loquai, C.. Department of Dermatology, University Hospital Mainz, Mainz
    • Weishaupt, C.. Department of Dermatology, University Hospital Münster, Münster
    • Gutzmer, R.. Department of Dermatology, Hannover Medical School, Hannover
    • Schuster, B.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Gleisner, S.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Schulze, B.. Department of Radiation Oncology, University Hospital Frankfurt, Frankfurt, Germany
    • Goldinger, S. M.. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    • Berking, C.. Department of Dermatology, University Hospital München (LMU), München
    • Forschner, A.. Department of Dermatology, University Hospital Tübingen, Tübingen, Germany
    • Clemens, P.. Department of Radiation Oncology, Hospital Feldkirch, Feldkirch, Austria
    • Grabenbauer, G.. Department of Radiation Oncology, Hospital Coburg, Coburg
    • Müller-Brenne, T.. Department of Radiation Oncology, University Hospital Mainz, Mainz
    • Bauch, J.. Department of Radiation Oncology, University Hospital Münster, Münster
    • Eich, H. T.. Department of Radiation Oncology, University Hospital Münster, Münster
    • Grabbe, S.. Department of Dermatology, University Hospital Mainz, Mainz
    • Schadendorf, D.. Department of Dermatology, University Hospital Essen, Essen
    • Schuler, G.. Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    • Keikavoussi, P.. Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    • Semrau, S.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Fietkau, R.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Distel, L. V.. Department of Radiation Oncology, University Hospital Erlangen, Erlangen
    • Heinzerling, L.. Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 2015, vol. 26, no. 6, p. 1238-1244. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:303268
    Summary
    This study shows radiosensitization by BRAF inhibitors in clinical practice and ex vivo by fluorescence in situ hybridization of chromosomal breaks. Nevertheless, radiotherapy with concomitant BRAF inhibitor therapy is feasible with an acceptable increase in toxicity. Vemurafenib is a more potent radiosensitizer than dabrafenib in both the patient study and the ex vivo experiments