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Polyclonal Proliferation of Large Granular Lymphocytes during Cytomegalovirus Primary Infection in a Human Immunodeficiency Virus—Infected Patient Receiving Antiretroviral Therapy

Kronenberg, Andreas ; Seebach, Jörg D. ; Bossart, Walter ; Weber, Rainer

In: Clinical Infectious Diseases, 2001, vol. 33, no. 5, p. e34-e36

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    Title
    • Polyclonal Proliferation of Large Granular Lymphocytes during Cytomegalovirus Primary Infection in a Human Immunodeficiency Virus—Infected Patient Receiving Antiretroviral Therapy
    Author
    • Kronenberg, Andreas. Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zürich
    • Seebach, Jörg D.. Laboratory for Transplantation Immunology, Department of Internal Medicine, University Hospital of Zürich
    • Bossart, Walter. Institute of Clinical Virology, University of Zürich
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zürich
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2001, vol. 33, no. 5, p. e34-e36. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:302821
    Summary
    We report the first case of a patient infected with HIV in whom polyclonal CD8+/CD57- T lymphocyte large granular lymphocyte (LGL) proliferation was observed in association with cytomegalovirus primary infection. Because the differential diagnosis of an increased number of LGLs includes both monoclonal LGL leukemia and polyclonal proliferation of LGL, patients in whom LGL proliferation is detected always need close hematological and clinical observation to determine whether therapeutic intervention is necessary