Fulltext

Efficacy of oral citrate administration in primary hyperoxaluria

Leumann, E. ; Hoppe, B. ; Neuhaus, T. ; Blau, N.

In: Nephrology Dialysis Transplantation, 1995, vol. 10, p. 14-16

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    Title
    • Efficacy of oral citrate administration in primary hyperoxaluria
    Author
    • Leumann, E.. University Children's Hospital, Zurich, Switzerland
    • Hoppe, B.. University Children's Hospital, Zurich, Switzerland
    • Neuhaus, T.. University Children's Hospital, Zurich, Switzerland
    • Blau, N.. University Children's Hospital, Zurich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Nephrology Dialysis Transplantation, 1995, vol. 10, p. 14-16. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:302014
    Summary
    Urinary citrate is a potent inhibitor of calcium oxalate (CaOx) crystallization, but oral citrate has rarely been used in patients with primary hyperoxaluria (PH). We studied the effect of sodium citrate administration (0.1-0.15 g/kg/day) on urinary citrate excretion and CaOx saturation in seven paediatric patients and the clinical response to long-term treatment (average 4 years) in five patients. Urinary citrate increased from 0.73 to 2.54 mmol/24h/l.73 m2 and urinary saturation for CaOx (calculated by equil 2) decreased from 11.41 to 6.79 (for both, p<0.02). Long-term administration of alkali citrate [0.15 g (0.5 mmol)/kg/day] resulted in stable or improved renal function in three and slow deterioration in two partially non-compliant patients. Alkali citrate is effective in patients with PH