Fulltext

Inspired oxygen fraction after cardiopulmonary bypass: effects on pulmonary function with regard to endothelin-1 concentrations and venous admixture

Reber, A. ; Budmiger, B. ; Wenk, M. ; Haefeli, W. E. ; Wolff, T. ; Bein, T. ; Skarvan, K.

In: British Journal of Anaesthesia, 2000, vol. 84, no. 5, p. 565-570

Ajouter à la liste personnelle
    Titre
    • Inspired oxygen fraction after cardiopulmonary bypass: effects on pulmonary function with regard to endothelin-1 concentrations and venous admixture
    Auteur
    • Reber, A.. Department of Anaesthesia, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    • Budmiger, B.. Department of Anaesthesia, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    • Wenk, M.. Department of Clinical Pharmacology, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    • Haefeli, W. E.. Department of Clinical Pharmacology, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    • Wolff, T.. Department of Cardiothoracic Surgery, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    • Bein, T.. Department of Anaesthesiology, University Hospital, D-93042 Regensburg, Germany
    • Skarvan, K.. Department of Anaesthesia, University of Basel/Kantonsspital, CH-4031 Basel, Switzerland.
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Anaesthesia, 2000, vol. 84, no. 5, p. 565-570. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301807
    Summary
    Twenty consecutive patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were allocated at random to group 1 (n=10, high inspired oxygen fraction (F𝒾O2) after CPB), or group 2 (n=10, moderate F𝒾O2 after CPB). The effects of each F𝒾O2 on arterial and mixed venous concentrations of endothelin-1 (ET-1) and its precursor, Big ET-1, were measured. Venous admixture was calculated to assess the efficiency of pulmonary gas exchange. Patients whose lungs had been ventilated with a F𝒾O2 of 1.0 (exposure time 70 min) after weaning from the CPB machine had significantly greater arterial and mixed venous Big ET-1 concentrations and venous admixture than patients whose lungs were ventilated with a F𝒾O2 of 0.35. In contrast, ET-1 concentrations in the two groups were not significantly different. A reduction of F𝒾O2 from 1.0 to 0.6 reduced venous admixture without lowering endothelial peptide concentrations. On the first postoperative day all peptide concentrations were similar in the two groups, whereas venous admixture remained non-significantly higher in group 1. A short period of high F𝒾O2 immediately after CPB increases endothelin concentrations and pulmonary venous admixture