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Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update

Glauser, M. P. ; Heumann, D. ; Baumgartner, J. D. ; Cohen, J.

In: Clinical Infectious Diseases, 1994, vol. 18, no. Supplement_2, p. S205-S216

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    Titre
    • Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update
    Auteur
    • Glauser, M. P.. Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, London, Switzerland, United Kingdom
    • Heumann, D.. Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, London, Switzerland, United Kingdom
    • Baumgartner, J. D.. Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, London, Switzerland, United Kingdom
    • Cohen, J.. Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, London, Switzerland, United Kingdom
    Type de document
    • Postprint
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301574
    Summary
    Septic shock is mediated by complex interactions of cells, cytokines, and humoral pathways. Clinical therapeutic strategies aimed at inhibiting selected pathways have been efficacious in subsets of patients. Experimental studies focusing on the activities of single cytokines have contributed to the understanding of the complex pathophysiology of septic shock. More precise delineation of the roles of each mechanism contributing to pathogenesis will permit the identification of subsets of patients who might benefit from particular therapeutic strategies and will guide the development of additional approaches to prevention and treatment