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Metabolic syndrome and the risk of breast cancer in postmenopausal women

Rosato, V. ; Bosetti, C. ; Talamini, R. ; Levi, F. ; Montella, M. ; Giacosa, A. ; Negri, E. ; La Vecchia, C.

In: Annals of Oncology, 2011, vol. 22, no. 12, p. 2687-2692

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    Titre
    • Metabolic syndrome and the risk of breast cancer in postmenopausal women
    Auteur
    • Rosato, V.. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan
    • Bosetti, C.. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan
    • Talamini, R.. Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    • Levi, F.. Cancer Epidemiology Unit and Cancer Registry of Vaud, Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    • Montella, M.. Department of Epidemiology, Istituto Nazionale Tumori "Fondazione Pascale”, Naples
    • Giacosa, A.. Department of Gastroenterology and Nutrient Unit, Policlinico di Monza, Monza
    • Negri, E.. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan
    • La Vecchia, C.. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 2011, vol. 22, no. 12, p. 2687-2692. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301558
    Summary
    Background: Only a few small studies investigated the association between postmenopausal breast cancer and metabolic syndrome (MetS) as a single entity. Materials and methods: We analyzed the data of two Italian and Swiss case-control studies conducted between 1983 and 2007, including 3869 postmenopausal women with incident breast cancer and 4082 postmenopausal controls admitted to the same hospitals as cases for acute conditions. MetS was defined as the presence of at least three components among diabetes, drug-treated hypertension, drug-treated hyperlipidemia, and obesity. Results: The odds ratios (ORs) of postmenopausal breast cancer were 1.33 [95% confidence interval (CI) 1.09-1.62] for diabetes, 1.19 (95% CI 1.07-1.33) for hypertension, 1.08 (95% CI 0.95-1.22) for hyperlipidemia, 1.26 (95% CI 1.11-1.44) for body mass index ≥30 kg/m2, and 1.22 (95% CI 1.09-1.36) for waist circumference ≥88 cm. The risk of postmenopausal breast cancer was significantly increased for women with MetS (OR = 1.75, 95% CI 1.37-2.22, for three or more MetS components, P for trend for increasing number of components < 0.0001) and the risk was higher at older age (OR = 3.04, 95% CI 1.75-5.29, at age ≥70 years for three or more MetS components). Conclusions: This study supports a direct association between MetS and postmenopausal breast cancer risk