Transdermal β-Blocker Therapy in Essential Hypertension
Spieker, Claus ; Vetter, Hans ; Liedtke, Rainer ; Zidek, Walter ; Vetter, Wilhelm
In: American Journal of Hypertension, 1988, vol. 1, no. 3_Pt_3, p. 199S-200S
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- Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and increase the patients compliance. In our study, we demonstrated that transdermal application of a ß-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 ±6.1 mm Hg/95.8 ± 8.3 mm Hg vs 136.8 ± 7.2 mm Hg/84.3 ± 5.0 mm Hg; Ρ < 0.05). A controlled study of transdermal versus oral ß-blocker administration in hypertensives is necessary before this new therapeutic system is introduced in antihypertensive treatment. Am J Hypertens 1988; 1:199S-200S