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In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide

Chuard, C. ; Rohner, P. ; Dunand, V. ; Auckenthaler, R. ; Lew, D.P.

In: Journal of Antimicrobial Chemotherapy, 1992, vol. 30, no. 3, p. 327-337

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    Titre
    • In-vitro and in-vivo evaluation of the antistaphylococcal activity of S-5556, a new 16-membered macrolide
    Auteur
    • Chuard, C.. Division of Infectious Diseases, University Hospital, CH-1211, Geneva 4, Switzerland
    • Rohner, P.. Division of Infectious Diseases, University Hospital, CH-1211, Geneva 4, Switzerland
    • Dunand, V.. Division of Infectious Diseases, University Hospital, CH-1211, Geneva 4, Switzerland
    • Auckenthaler, R.. Division of Infectious Diseases, University Hospital, CH-1211, Geneva 4, Switzerland
    • Lew, D.P.. Division of Infectious Diseases, University Hospital, CH-1211, Geneva 4, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1992, vol. 30, no. 3, p. 327-337. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300476
    Summary
    During recent years, a resurgence of interest in the macrolides had led to the discovery of new derivatives of erythromycin with improved antibacterial activity and pharmacokinetic properties. In this study the in-vitro and in-vivo antistaphylococcal activity of S-5556, a 16-membered macrolide, was evaluated. In vitro, S-5556 was slightly less active than erythromycin against methicillin-susceptible Staphylococcus aureus. In contrast, it had superior activity for methicillin-resistant S. aureus (MRSA); several of these strains with inducible resistance to the macrolides-lincosamides-streptogramins group were susceptible to S-5556 whereas erythromycin was inactive. The combination of S-5556 with oxatillin was synergic for most MRSA strains tested. In vivo, a single prophylactic dose of S-5556 prevented 75%-100% of the cases of acute staphylococcal subcutaneous foreign body infection in a guinea pig-model. In a rat-model of chronic implant infection due to a methicillin- and erythromycin-resistant S. aureus strain, S-5556 significantly decreased the bacteria] concentration around the foreign material, however resistant mutants emerged