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Excretion of Cannabinoids in Urine after Ingestion of Cannabis Seed Oil

Lehmann, T. ; Sager, F. ; Brenneisen, R.

In: Journal of Analytical Toxicology, 1997, vol. 21, no. 5, p. 373-375

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    Titre
    • Excretion of Cannabinoids in Urine after Ingestion of Cannabis Seed Oil
    Auteur
    • Lehmann, T.. Institute of Pharmacy, University of Bern, Baltzerstrasse 5, CH-3012 Bern, Switzerland
    • Sager, F.. Swiss Federal Office of Public Health, Division of Food Science, CH-3097 Liebefeld, Switzerland
    • Brenneisen, R.. Institute of Pharmacy, University of Bern, Baltzerstrasse 5, CH-3012 Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Analytical Toxicology, 1997, vol. 21, no. 5, p. 373-375. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300324
    Summary
    Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined Δ9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 µg/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 µg/g), was collected for six days. The urine samples were screened by immunoassay, and the content of 11-nor-9-carboxy-Δ9-THC (THCCOOH) was determined by GC-MS. Urine samples were found cannabis positive for up to six days with THCCOOH-equivalent concentrations up to 243 ng/ml, by the Abuscreen OnLine immunoassay and THCCOOH contents from 5 to 431 ng/mL by the GC-MS method. All subjects reported THC-specific psychotropic effects