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Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients

Cappuzzo, F. ; Tallini, G. ; Finocchiaro, G. ; Wilson, R. S. ; Ligorio, C. ; Giordano, L. ; Toschi, L. ; Incarbone, M. ; Cavina, R. ; Terracciano, L. ; Roncalli, M. ; Alloisio, M. ; Varella-Garcia, M. ; Franklin, W. A. ; Santoro, A.

In: Annals of Oncology, 2009, vol. 21, no. 3, p. 562-567

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    Titre
    • Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients
    Auteur
    • Cappuzzo, F.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Tallini, G.. Department of Pathology, Ospedale Bellaria, Bologna, Italy
    • Finocchiaro, G.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Wilson, R. S.. University of Colorado Cancer Center, Aurora, CO, USA
    • Ligorio, C.. Department of Pathology, Ospedale Bellaria, Bologna, Italy
    • Giordano, L.. Statitistic Unit, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    • Toschi, L.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Incarbone, M.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Cavina, R.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Terracciano, L.. Division of Molecular Pathology, University Hospital, Basel, Switzerland
    • Roncalli, M.. Department of Pathology, University of Milan School of Medicine, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    • Alloisio, M.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    • Varella-Garcia, M.. University of Colorado Cancer Center, Aurora, CO, USA
    • Franklin, W. A.. University of Colorado Cancer Center, Aurora, CO, USA
    • Santoro, A.. Department of Oncology-Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico (IRCCS), Rozzano
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 2009, vol. 21, no. 3, p. 562-567. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299904
    Summary
    Background: The purpose of this study is to investigate the prognostic role of insulin-like growth factor receptor 1 (IGF1R) expression in surgically resected non-small-cell lung cancer (NSCLC). Patient characteristics and methods: This retrospective study was conducted in 369 stage I-II-IIIA, surgically resected, NSCLC patients. Patients exposed to anti-epidermal growth factor receptor (EGFR) agents were excluded. IGF1R expression was evaluated by immunohistochemistry in tissue microarray sections. Results: A positive IGF1R expression (score ≥ 100) was observed in 282 cases (76.4%) and was significantly associated with squamous cell histology (P = 0.04) and with grade III differentiation (P = 0.02). No difference in survival was observed between the positive and negative group when score 100 was used as cut-off for discriminating a positive versus a negative IGF1R result (52 versus 48 months, P = 0.99) or when median value of IGF1R expression was used (45 versus 55 months, P = 0.36). No difference in survival was observed between IGF1R-positive and -negative patients in a subgroup of stage I-II adenocarcinoma (n = 137) with known EGFR mutation and copy number status. Conclusions: IGF1R expression does not represent a prognostic factor in resected NSCLC patients. Patients with squamous cell carcinoma overexpress IGF1R more frequently than patients with nonsquamous histology, justifying the different sensitivity to anti-IGF1R agents observed in clinical trials