Fulltext

Sex hormones and hypertension

Dubey, Raghvendra K. ; Oparil, Suzanne ; Imthurn, Bruno ; Jackson, Edwin K.

In: Cardiovascular Research, 2002, vol. 53, no. 3, p. 688-708

Ajouter à la liste personnelle
    Titre
    • Sex hormones and hypertension
    Auteur
    • Dubey, Raghvendra K.. Center for Clinical Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    • Oparil, Suzanne. The Vascular Biology and Hypertension Program, University of Alabama, Birmingham, AL 35294, USA
    • Imthurn, Bruno. University Hospital Zurich, Department of Obstetrics and Gynecology, Clinic for Endocrinology, Frauenklinikstrasse 10, 8091 Zurich, Switzerland
    • Jackson, Edwin K.. Center for Clinical Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299884
    Summary
    Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are responsible for the observed gender-associated differences in arterial blood pressure and whether ovarian hormones account for differences in blood pressure in premenopausal versus postmenopausal women remains unclear. In this review, we provide a discussion of the potential blood pressure regulating effects of female and male sex hormones, as well as the cellular, biochemical and molecular mechanisms by which sex hormones may modify the effects of hypertension on the cardiovascular system