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Immunosuppressive therapy in lung transplantation: state of the art

Korom, Stephan ; Boehler, Annette ; Weder, Walter

In: European Journal of Cardio-Thoracic Surgery, 2009, vol. 35, no. 6, p. 1045-1055

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    Titre
    • Immunosuppressive therapy in lung transplantation: state of the art
    Auteur
    • Korom, Stephan. Zurich Lung Transplantation Group, Division of Thoracic Surgery, University Hospital, Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland
    • Boehler, Annette. Zurich Lung Transplantation Group, Division of Pulmonary Medicine, University Hospital, Zurich, Zurich, Switzerland
    • Weder, Walter. Zurich Lung Transplantation Group, Division of Thoracic Surgery, University Hospital, Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Cardio-Thoracic Surgery, 2009, vol. 35, no. 6, p. 1045-1055. Elsevier Science B.V.
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299836
    Summary
    The coming of age of lung transplantation is accompanied by an immunosuppressive armamentarium that has been brought forward from other transplant indications. Widely employed on the basis of few small randomized studies, and mostly single-center experience or empirical expert knowledge, anti-rejection therapeutic strategies in pulmonary transplantation have hardly been rigorously evaluated in large-scale prospective international trials. This review compiles the available findings on the use of current immunosuppressants in clinical lung transplantation, accentuating high level-of-evidence study results. Reporting on recent meeting and registry data, and assembling ongoing relevant trials from international databases, this article serves as an update on the state of the art of immunosuppression in lung transplantation