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Combined Use of Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis

Rozot, Virginie ; Patrizia, Amelio ; Vigano, Selena ; Mazza-Stalder, Jesica ; Idrizi, Elita ; Day, Cheryl L. ; Perreau, Matthieu ; Lazor-Blanchet, Catherine ; Ohmiti, Khalid ; Goletti, Delia ; Bart, Pierre-Alexandre ; Hanekom, Willem ; Scriba, Thomas J. ; Nicod, Laurent ; Pantaleo, Giuseppe ; Harari, Alexandre

In: Clinical Infectious Diseases, 2015, vol. 60, no. 3, p. 432-437

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    Titre
    • Combined Use of Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis
    Auteur
    • Rozot, Virginie. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Patrizia, Amelio. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Vigano, Selena. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Mazza-Stalder, Jesica. Division of Pneumology
    • Idrizi, Elita. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Day, Cheryl L.. South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    • Perreau, Matthieu. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Lazor-Blanchet, Catherine. Occupational Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    • Ohmiti, Khalid. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Goletti, Delia. National Institute for Infectious Diseases, Rome, Italy
    • Bart, Pierre-Alexandre. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Hanekom, Willem. South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    • Scriba, Thomas J.. South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    • Nicod, Laurent. Division of Pneumology
    • Pantaleo, Giuseppe. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    • Harari, Alexandre. Division of Immunology and Allergy, Lausanne University Hospital, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Clinical Infectious Diseases, 2015, vol. 60, no. 3, p. 432-437. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299788
    Summary
    Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection